Inactivated whole-cell (killed antigen) vaccines
Inactivated vaccines are made from microorganisms (viruses, bacteria, other) that have been killed through physical or chemical processes. These killed organisms cannot cause disease.
- Inactivated whole-cell vaccines may not always induce an immune response and the response may not be long lived.
- Several doses of inactivated whole-cell vaccines may be required to evoke a sufficient immune response.
Safety and stability
- Inactivated whole-cell vaccines have no risk of inducing the disease they are given against as they do not contain live components.
- They are considered more stable than LAV vaccines.
The table lists the rare, more severe adverse reactions of these vaccines. Note the frequency of the adverse reactions to get an idea of how low or high the possibility of an adverse event is. Also read the Comments to understand additional context details on the adverse events.
Adverse reactions associated with inactivated whole-cell vaccines
Which of the following statements is incorrect?
|A. Inactivated whole-cell vaccines contain "killed" pathogens.|
|B. Inactivated whole-cell vaccines can be considered safer than live vaccines, particularly when used in vulnerable groups (immunocompromised persons).|
|C. Inactivated whole-cell vaccines can be considered more effective compared to live vaccines.|
|D. Inactivated whole-cell vaccines should not be seen as ineffective – the immunization schedule foresees repeated doses to ensure adequate immune responses in patients.|
Answer C is incorrect.
- Inactivated vaccines can be considered safer than live vaccines, which, however, comes with a reduced effectiveness of the vaccine. Inactivated vaccines should not be seen as ineffective – the immunization schedule foresees repeated doses to ensure adequate immune responses in patients.
- Live vaccines on the other hand should not be seen as unsafe – their production is usually done with meticulous quality checks ensuring their safety. It is rather important to have well trained health staff screening patients for counter indications to the vaccines.